Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinical and Genetic Implications of Mutation Burden in Squamous Cell Carcinoma of the Lung.

Annals of surgical oncology - 1 Jun 2018

Okamoto Tatsuro, Takada Kazuki, Sato Seijiro, Toyokawa Gouji, Tagawa Tetsuzo, Shoji Fumihiro, Nakanishi Ryota, Oki Eiji, Koike Terumoto, Nagahashi Masayuki, Ichikawa Hiroshi, Shimada Yoshifumi, Watanabe Satoshi, Kikuchi Toshiaki, Akazawa Kouhei, Lyle Stephen, Takabe Kazuaki, Okuda Shujiro, Sugio Kenji, Wakai Toshifumi, Tsuchida Masanori, Maehara Yoshihiko

Abstract excerpt

BACKGROUND: Lung squamous cell carcinoma (LSCC) is a major histological subtype of lung cancer. In this study, we investigated genomic alterations in LSCC and evaluated the clinical implications of mutation burden (MB) in LSCC. METHODS: Genomic alterations were determined in Japanese patients with LSCC (N = 67) using next-generation sequencing of 415 known cancer genes. MB was defined as the number of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B7-H1 Antigen
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p15

Share to Neoplasm Grading

Share to Protein-Tyrosine Kinases

Share to PTEN Phosphohydrolase

Share to SOXB1 Transcription Factors

Source

Identifiers

PMID: 29500766
DOI: 10.1245/s10434-018-6401-1

Genes

SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinical and Genetic Implications of Mutation Burden in Squamous Cell Carcinoma of the Lung.PMID 29500766Read ↗

Association Between Tumor Mutation Burden (TMB) and immune microenvironment in lung squamous cell carcinomaSemantic proximity Read ↗

Tumor Mutational Burden and Genomic Alterations in Chinese Small Cell Lung Cancer Measured by Whole-Exome Sequencing.Semantic proximity Read ↗

Tumor Mutation Burden May be a Prognostic Biomarker of Long-Term Survival in Resected Small-Cell Lung CancerSemantic proximity Read ↗

Comprehensive genomic profiling of small cell lung cancer in Chinese patients and the implications for therapeutic potentialSemantic proximity Read ↗

The co-mutation of EGFR and tumor-related genes leads to a worse prognosis and a higher level of tumor mutational burden in Chinese non-small cell lung cancer patientsSemantic proximity Read ↗

Prognostic impact of tumor mutation burden and the mutation in KIAA1211 in small cell lung cancer.Semantic proximity Read ↗

Comparative study on the mutational profile of adenocarcinoma and squamous cell carcinoma predominant histologic subtypes in Chinese non-small cell lung cancer patients.Semantic proximity Read ↗

Genomic landscape and its correlations with tumor mutational burden, PD-L1 expression, and immune cells infiltration in Chinese lung squamous cell carcinomaSemantic proximity Read ↗

Genetic changes in squamous cell lung cancer: a review.Semantic proximity Read ↗

Genetic alteration profiling of patients with resected squamous cell lung carcinomas.Semantic proximity Read ↗

TP53 and CDKN2A mutations in patients with early-stage lung squamous cell carcinoma: an analysis of the correlations and prognostic outcomesSemantic proximity Read ↗

Analysis of ultra-deep targeted sequencing reveals mutation burden is associated with gender and clinical outcome in lung adenocarcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.