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Targeted Liquid Biopsy Using Irradiation to Facilitate the Release of Cell-Free DNA from a Spatially Aimed Tumor Tissue.

Cancer research and treatment - 1 Jan 2022

Noh Jae Myoung, Kim Yeon Jeong, Lee Ho Yun, Choi Changhoon, Ahn Won-Gyun, Lee Taeseob, Pyo Hongryull, Park Jee Hyun, Park Donghyun, Park Woong-Yang

Abstract excerpt

PURPOSE: We investigated the feasibility of using an anatomically localized, target-enriched liquid biopsy (TLB) in mouse models of lung cancer. MATERIALS AND METHODS: After irradiating xenograft mouse with human lung cancer cell lines, H1299 (NRAS proto-oncogene, GTPase [NRAS] Q61K) and HCC827 (epidermal growth factor receptor [EGFR] E746-750del), circulating (cell-free) tumor DNA (ctDNA) levels were monitored...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34044476
DOI: 10.4143/crt.2021.151
PMCID: PMC8756125

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