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Metabolic characterization of directly reprogrammed renal tubular epithelial cells (iRECs)

23 Feb 2018

Abstract excerpt

Fibroblasts can be directly reprogrammed to induced renal tubular epithelial cells (iRECs) using four transcription factors. These engineered cells may be used for disease modeling, cell replacement therapy or drug and toxicity testing. Direct reprogramming induces drastic changes in the transcriptional landscape, protein expression, morphological and functional properties of cells. However, how the metabolome is...

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PMID: 29497074
DOI: 10.1038/s41598-018-22073-7

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