Article
Molecular characterization of acquired tolerance of tumor cells to picropodophyllin (PPP).
PloS one - 14 Mar 2011
Hashemi Jamileh, Worrall Claire, Vasilcanu Daiana, Fryknäs Mårten, Sulaiman Luqman, Karimi Mohsen, Weng Wen-Hui, Lui Weng-Onn, Rudduck Christina, Axelson Magnus, Jernberg-Wiklund Helena, Girnita Leonard, Larsson Olle, Larsson Catharina
Abstract excerpt
BACKGROUND: Picropodophyllin (PPP) is a promising novel anti-neoplastic agent that efficiently kills tumor cells in vitro and causes tumor regression and increased survival in vivo. We have previously reported that PPP treatment induced moderate tolerance in two out of 10 cell lines only, and here report the acquired genomic and expression alterations associated with PPP selection over 1.5 years of treatment....
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