Article
Droplet digital polymerase chain reaction assay and peptide nucleic acid-locked nucleic acid clamp method for RHOA mutation detection in angioimmunoblastic T-cell lymphoma.
Cancer science - 1 May 2018
Tanzima Nuhat Sharna, Sakata-Yanagimoto Mamiko, Komori Daisuke, Hattori Keiichiro, Suehara Yasuhito, Fukumoto Kota, Fujisawa Manabu, Kusakabe Manabu, Matsue Kosei, Wakamatsu Hirotake, Shimadzu Mitsunobu, Chiba Shigeru
Abstract excerpt
Angioimmunoblastic T-cell lymphoma (AITL) is a subtype of nodal peripheral T-cell lymphoma (PTCL). Somatic RHOA mutations, most frequently found at the hotspot site c.50G > T, p.Gly17Val (G17V RHOA mutation) are a genetic hallmark of AITL. Detection of the G17V RHOA mutations assists prompt and appropriate diagnosis of AITL. However, an optimal detection method for the G17V RHOA mutation remains to be elucidated....
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