Article
Characterization and clinical enrichment of HLA-C*07:02-restricted Cytomegalovirus-specific CD8+ T cells.
PloS one - 1 Jan 2018
Schlott Fabian, Steubl Dominik, Ameres Stefanie, Moosmann Andreas, Dreher Stefan, Heemann Uwe, Hösel Volker, Busch Dirk H, Neuenhahn Michael
Abstract excerpt
Human Cytomegalovirus (CMV) reactivation remains a major source of morbidity in patients after solid organ and hematopoietic stem cell transplantation (HSCT). Adoptive T cell therapy (ACT) with CMV-specific T cells is a promising therapeutic approach for HSCT recipients, but might be counteracted by CMV's immune evasion strategies. HLA-C*07:02 is less susceptible to viral immune evasion suggesting...
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