Article
Gut microbiome heritability is nearly universal but environmentally contingent.
Science (New York, N.Y.) - 9 Jul 2021
Grieneisen Laura, Dasari Mauna, Gould Trevor J, Björk Johannes R, Grenier Jean-Christophe, Yotova Vania, Jansen David, Gottel Neil, Gordon Jacob B, Learn Niki H, Gesquiere Laurence R, Wango Tim L, Mututua Raphael S, Warutere J Kinyua, Siodi Long'ida, Gilbert Jack A, Barreiro Luis B, Alberts Susan C, Tung Jenny, Archie Elizabeth A, Blekhman Ran
Abstract excerpt
Relatives have more similar gut microbiomes than nonrelatives, but the degree to which this similarity results from shared genotypes versus shared environments has been controversial. Here, we leveraged 16,234 gut microbiome profiles, collected over 14 years from 585 wild baboons, to reveal that host genetic effects on the gut microbiome are nearly universal. Controlling for diet, age, and socioecological...
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