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Article

Impact of Chemical-Induced Mutational Load Increase on Immune Checkpoint Therapy in Poorly Responsive Murine Tumors.

Molecular cancer therapeutics - 1 Apr 2018

Kuczynski Elizabeth A, Krueger Janna, Chow Annabelle, Xu Ping, Man Shan, Sundaravadanam Yogi, Miller Jessica K, Krzyzanowski Paul M, Kerbel Robert S

Abstract excerpt

A recurring historic finding in cancer drug development is encouraging antitumor effects observed in tumor-bearing mice that fail to translate into the clinic. An intriguing exception to this pattern is immune checkpoint therapy, as the sustained tumor regressions observed in subsets of cancer patients are rare in mice. Reasoning that this may be due in part to relatively low mutational loads of mouse tumors, we...

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PMID: 29483207
DOI: 10.1158/1535-7163.MCT-17-1091

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