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Early evolution of BRAFV600 status in the blood of melanoma patients correlates with clinical outcome and identifies patients refractory to therapy.

Melanoma research - 1 Jun 2018

Gonzalez-Cao Maria, Mayo de Las Casas Clara, Jordana Ariza Nuria, Manzano Jose L, Molina-Vila Miguel Á, Soriano Virtudes, Puertolas Teresa, Balada Ariadna, Soria Ainara, Majem Margarita, Montagut Clara, Muñoz Eva, Rodriguez-Abreu Delvys, Perez Elisabeth, Garcia Almudena, Cortes Javier, Drozdowskyj Ana, Karachaliou Niki, Rosell Rafael

Abstract excerpt

Serial analysis of BRAF mutations in circulating-free DNA (cfDNA) could be of prognostic value in melanoma patients. We collected blood samples from 63 advanced BRAFV600E/K melanoma patients and determined BRAFV600E/K status in cfDNA using a quantitative 5'-nuclease PCR-based assay. Levels of BRAF mutation in pre-cfDNAs were associated significantly with tumour burden, progression-free survival and overall...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 29481492
DOI: 10.1097/CMR.0000000000000432

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BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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