Article

Duvelisib Eliminates CLL B Cells, Impairs CLL-Supporting Cells, and Overcomes Ibrutinib Resistance in Preclinical Models

2021-07-21

Abstract excerpt

<title>Abstract</title> <p>Inhibitors of Bruton’s Tyrosine Kinase (BTKi) and phosphoinositide 3-kinase (PI3Ki) have significantly improved therapy of chronic lymphocytic leukemia (CLL). However, the emergence of resistance to BTKi has introduced an unmet therapeutic need. Here we demonstrate <italic>in vitro</italic> and <italic>in vivo</italic> the essential roles of PI3K-δ for CLL B-cell survival and migration...

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Literature Corpus work: c961bac8-3769-5d40-9396-1f21a00afabe
DOI: 10.21203/rs.3.rs-701669/v1

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