Article
Genetic risk prediction: individualized variability in susceptibility to toxicants.
Annual review of pharmacology and toxicology - 1 Jan 2013
Nebert Daniel W, Zhang Ge, Vesell Elliot S
Abstract excerpt
Genetic risk prediction uses genetic data to individualize prediction of outcome or effect from a known harmful toxicant. Several examples of toxicogenetics (usually binary traits) are discussed, reflecting largely Mendelian traits before the Human Genome Project began in 1990. Numerous complexities of the genome and what constitutes "a gene" have emerged during these past two decades. Examples of toxicogenomics...
Topics
- Animals
- Environment
- Genetic Predisposition to Disease
- Hazardous Substances
- Humans
- Risk Assessment
- Toxicogenetics
- Xenobiotics