Article
Toxicological considerations in the application and interpretation of susceptibility biomarkers in epidemiological studies.
IARC scientific publications - 1 Jan 2004
De Roos Anneclaire J, Smith Martyn T, Chanock Stephen, Rothman Nathaniel
Abstract excerpt
With major advances in genotyping technology, it has become practical and affordable to screen biological samples for multiple polymorphisms for which there is more or less knowledge about their functional relevance in relation to toxicological agents or disease. This situation creates some unique epidemiological challenges in which careful consideration of the mechanisms underlying genotype-disease and...
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