Article
Guanosine tetra- and pentaphosphate increase antibiotic tolerance by reducing reactive oxygen species production in Vibrio cholerae.
The Journal of biological chemistry - 13 Apr 2018
Kim Hwa Young, Go Junhyeok, Lee Kang-Mu, Oh Young Taek, Yoon Sang Sun
Abstract excerpt
The pathogen Vibrio cholerae is the causative agent of cholera. Emergence of antibiotic-resistant V. cholerae strains is increasing, but the underlying mechanisms remain unclear. Herein, we report that the stringent response regulator and stress alarmone guanosine tetra- and pentaphosphate ((p)ppGpp) significantly contributes to antibiotic tolerance in V. cholerae We found that N16961, a pandemic V. cholerae...
Topics
- Drug Resistance, Bacterial
- Gene Expression Regulation, Bacterial
- Guanosine Pentaphosphate
- Guanosine Tetraphosphate
- Mutation
- Periplasmic Binding Proteins
- Reactive Oxygen Species
- Vibrio cholerae