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Article

Broad blocking of MDR efflux pumps by acetylshikonin and acetoxyisovalerylshikonin to generate hypersensitive phenotype of malignant carcinoma cells.

Scientific reports - 22 Feb 2018

Mirzaei Seyed Abbas, Reiisi Somayeh, Ghiasi Tabari Parmida, Shekari Abolfazl, Aliakbari Fatemeh, Azadfallah Elaheh, Elahian Fatemeh

Abstract excerpt

Cytotoxic activities of acetylshikonin and acetoxyisovalerylshikonin alone and in combination with chemotherapeutic agents against parental and drug resistant cell lines were determined using the MTT assay. Effects of Shikonin derivatives on BCRP, MDR1 and MRP transcript and protein levels were relatively measured. Finally, accumulation and efflux kinetics were conducted. The results revealed cell- and...

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PMID: 29472576
DOI: 10.1038/s41598-018-21710-5
PMCID: PMC5823906

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