Article
Targeted changes of the cell wall proteome influence Candida albicans ability to form single- and multi-strain biofilms.
PLoS pathogens - 1 Dec 2014
Cabral Vitor, Znaidi Sadri, Walker Louise A, Martin-Yken Hélène, Dague Etienne, Legrand Mélanie, Lee Keunsook, Chauvel Murielle, Firon Arnaud, Rossignol Tristan, Richard Mathias L, Munro Carol A, Bachellier-Bassi Sophie, d'Enfert Christophe
Abstract excerpt
Biofilm formation is an important virulence trait of the pathogenic yeast Candida albicans. We have combined gene overexpression, strain barcoding and microarray profiling to screen a library of 531 C. albicans conditional overexpression strains (∼10% of the genome) for genes affecting biofilm development in mixed-population experiments. The overexpression of 16 genes increased strain occupancy within a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.