Article
Lack of glyoxylate shunt dysregulates iron homeostasis in Pseudomonas aeruginosa.
Microbiology (Reading, England) - 1 Apr 2018
Ha Sunhee, Shin Bora, Park Woojun
Abstract excerpt
The aceA and glcB genes, encoding isocitrate lyase (ICL) and malate synthase, respectively, are not in an operon in many bacteria, including Pseudomonas aeruginosa, unlike in Escherichia coli. Here, we show that expression of aceA in P. aeruginosa is specifically upregulated under H2O2-induced oxidative stress and under iron-limiting conditions. In contrast, the addition of exogenous redox active compounds or...
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