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Cyclobutane pyrimidine dimers are predominant DNA lesions in whole human skin exposed to UVA radiation

5 Sept 2006

Abstract excerpt

Solar UV radiation is the most important environmental factor involved in the pathogenesis of skin cancers. The well known genotoxic properties of UVB radiation (290-320 nm) mostly involve bipyrimidine DNA photoproducts. In contrast, the contribution of more-abundant UVA radiation (320-400 nm) that are not directly absorbed by DNA remains poorly understood in skin. Using a highly accurate and quantitative assay...

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Identifiers

PMID: 16954188
DOI: 10.1073/pnas.0604213103

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Source receipt: pubmed, retrieved 7 Sept 2026.

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