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Article

MeCP2 mutant protein is expressed in astrocytes as well as in neurons and localizes in the nucleus.

Cytogenetic and genome research - 1 Jan 2010

Kifayathullah L A, Arunachalam J P, Bodda C, Agbemenyah H Y, Laccone F A, Mannan A U

Abstract excerpt

The MECP2 gene, located at Xq28, encodes methyl-CpG-binding protein 2 (MeCP2), which is frequently mutated (up to 90%) in Rett syndrome (RTT). RTT is a progressive neurodevelopmental disorder, which affects primarily girls during early childhood and it is one of the most common causes of mental retardation in females. R270X is one of the most frequent recurrent MECP2 mutations among RTT cohorts. The R270X...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20625242
DOI: 10.1159/000315906

Genes

MECP2
TRD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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