Article
Loss of adipose triglyceride lipase is associated with human cancer and induces mouse pulmonary neoplasia.
Oncotarget - 7 Jun 2016
Al-Zoughbi Wael, Pichler Martin, Gorkiewicz Gregor, Guertl-Lackner Barbara, Haybaeck Johannes, Jahn Stephan W, Lackner Carolin, Liegl-Atzwanger Bernadette, Popper Helmut, Schauer Silvia, Nusshold Elisa, Kindt Alida S D, Trajanoski Zlatko, Speicher Michael R, Haemmerle Guenther, Zimmermann Robert, Zechner Rudolf, Vesely Paul W, Hoefler Gerald
Abstract excerpt
Metabolic reprogramming is a hallmark of cancer. Understanding cancer metabolism is instrumental to devise innovative therapeutic approaches. Anabolic metabolism, including the induction of lipogenic enzymes, is a key feature of proliferating cells. Here, we report a novel tumor suppressive function for adipose triglyceride lipase (ATGL), the rate limiting enzyme in the triglyceride hydrolysis cascade.In...
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