Article
13C-phenylalanine breath test and serum biopterin in schizophrenia, bipolar disorder and major depressive disorder.
Journal of psychiatric research - 1 Apr 2018
Teraishi Toshiya, Kajiwara Masahiro, Hori Hiroaki, Sasayama Daimei, Hidese Shinsuke, Matsuo Junko, Ishida Ikki, Kajiwara Yasuhiro, Ozeki Yuji, Ota Miho, Hattori Kotaro, Higuchi Teruhiko, Kunugi Hiroshi
Abstract excerpt
Phenylalanine is required for the synthesis of the neurotransmitters dopamine, noradrenaline, and adrenaline. The rate-limiting step for phenylalanine metabolism is catalyzed by phenylalanine hydroxylase (PAH) and its cofactor tetrahydrobiopterin. We aimed to detect altered phenylalanine metabolism in major psychiatric disorders using the l-[1-13C]phenylalanine breath test (13C-PBT) and serum biopterin levels. We...
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