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Article

Evidence for a tetrahydrobiopterin deficit in schizophrenia.

Neuropsychobiology - 1 Jan 2005

Richardson M A, Read Laura L, Taylor Clelland Catherine L, Reilly Margaret A, Chao Helen M, Guynn Robert W, Suckow Raymond F, Clelland James D

Abstract excerpt

Tetrahydrobiopterin (BH(4)) is a vital cofactor maintaining availability of the amine neurotransmitters [dopamine (DA), noradrenaline (NA), and serotonin (5-HT)], regulating the synthesis of nitric oxide (NO) by nitric oxide synthase (NOS), and stimulating and modulating the glutamatergic system (directly and indirectly). These BH(4) properties and their potential relevance to schizophrenia led us to investigate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16244500
DOI: 10.1159/000089002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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