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Article

Diminished CXCR5 expression in peripheral blood of patients with Sjögren's syndrome may relate to both genotype and salivary gland homing.

Clinical and experimental immunology - 1 Jun 2018

Aqrawi L A, Ivanchenko M, Björk A, Ramírez Sepúlveda J I, Imgenberg-Kreuz J, Kvarnström M, Haselmayer P, Jensen J L, Nordmark G, Chemin K, Skarstein K, Wahren-Herlenius M

Abstract excerpt

Genetic investigations of Sjögren's syndrome (SS) have identified a susceptibility locus at p23.3 of chromosome 11, which contains the CXCR5 gene. C-X-C motif chemokine receptor 5 (CXCR5) is a chemokine receptor expressed on B and T cell subsets, and binds the chemotactic ligand C-X-C motif chemokine ligand 13 (CXCL13). In this study we aimed to link the genetic association with functional effects and explore the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 11

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Share to Polymorphism, Genetic

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Source

Open in PubMed Open full text

Identifiers

PMID: 29453859
DOI: 10.1111/cei.13118
PMCID: PMC5980494

Genes

CXCR5
CXCL13
CCR6
CXCR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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