Article
Regulation of disease susceptibility and mononuclear cell infiltration into the labial salivary glands of Sjögren's syndrome by monocyte chemotactic protein-1.
Rheumatology (Oxford, England) - 1 Aug 2010
Iwamoto Naoki, Kawakami Atsushi, Arima Kazuhiko, Nakamura Hideki, Kawashiri Shin-ya, Tamai Mami, Kita Junko, Okada Akitomo, Koga Tomohiro, Kamachi Makoto, Yamasaki Satoshi, Ichinose Kunihiro, Ida Hiroaki, Origuchi Tomoki, Eguchi Katsumi
Abstract excerpt
OBJECTIVE: To investigate how monocyte chemotactic protein-1 (MCP-1) is involved in the pathological process of primary SS (pSS). METHODS: Guanine (G) to adenine (A) single nucleotide polymorphism (SNP) of the -2518 MCP-1 promoter region in pSS and healthy controls was determined by the PCR-restriction fragment length polymorphism technique. Immunohistochemical staining towards MCP-1 and C-C motif chemokine...
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