Article
Autosomal dominant mannose-binding lectin deficiency is associated with worse neurodevelopmental outcomes after cardiac surgery in infants.
The Journal of thoracic and cardiovascular surgery - 1 Mar 2018
Kim Daniel Seung, Li Yatong K, Kim Jerry H, Bergquist Curtis S, Gerdes Marsha, Bernbaum Judy C, Burnham Nancy, McDonald-McGinn Donna M, Zackai Elaine H, Nicolson Susan C, Spray Thomas L, Nickerson Deborah A, Hakonarson Hakon, Jarvik Gail P, Gaynor J William
Abstract excerpt
OBJECTIVES: The MBL2 gene is the major genetic determinant of mannose-binding lectin (MBL)-an acute phase reactant. Low MBL levels have been associated with adverse outcomes in preterm infants. The MBL2Gly54Asp missense variant causes autosomal dominant MBL deficiency. We tested the hypothesis that MBL2Gly54Asp is associated with worse neurodevelopmental outcomes after cardiac surgery in neonates. METHODS: This...
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