Article
MBL2 gene polymorphisms increase the risk of adverse neurological outcome in preterm infants: a preliminary prospective study.
Pediatric research - 1 Nov 2014
Auriti Cinzia, Prencipe Giusi, Caravale Barbara, Coletti Maria Franca, Ronchetti Maria Paola, Piersigilli Fiammetta, Azzari Chiara, Di Ciommo Vincenzo M
Abstract excerpt
BACKGROUND: As described in animal models, the lectin-complement pathway is central to the propagation of ischemia-reperfusion injuries in many tissues, including the brain. Similarly, it might affect the genesis of brain damage in preterm infants. MBL2 gene single-nucleotide polymorphisms (SNPs), regulating mannose-binding lectin (MBL) serum levels, could predict the risk of adverse neurological outcome in these...
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