Article
Results of genome-wide analyses on neurodevelopmental phenotypes at four-year follow-up following cardiac surgery in infancy.
PloS one - 1 Jan 2012
Kim Daniel S, Stanaway Ian B, Rajagopalan Ramakrishnan, Bernbaum Judy C, Solot Cynthia B, Burnham Nancy, Zackai Elaine H, Clancy Robert R, Nicolson Susan C, Gerdes Marsha, Nickerson Deborah A, Hakonarson Hakon, Gaynor J William, Jarvik Gail P
Abstract excerpt
BACKGROUND: Adverse neurodevelopmental sequelae are reported among children who undergo early cardiac surgery to repair congenital heart defects (CHD). APOE genotype has previously been determined to contribute to the prediction of these outcomes. Understanding further genetic causes for the development of poor neurobehavioral outcomes should enhance patient risk stratification and improve both prevention and...
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