Article
Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma.
Scientific reports - 15 Feb 2018
Gharahkhani Puya, Burdon Kathryn P, Cooke Bailey Jessica N, Hewitt Alex W, Law Matthew H, Pasquale Louis R, Kang Jae H, Haines Jonathan L, Souzeau Emmanuelle, Zhou Tiger, Siggs Owen M, Landers John, Awadalla Mona, Sharma Shiwani, Mills Richard A, Ridge Bronwyn, Lynn David, Casson Robert, Graham Stuart L, Goldberg Ivan, White Andrew, Healey Paul R, Grigg John, Lawlor Mitchell, Mitchell Paul, Ruddle Jonathan, Coote Michael, Walland Mark, Best Stephen, Vincent Andrea, Gale Jesse, RadfordSmith Graham, Whiteman David C, Montgomery Grant W, Martin Nicholas G, Mackey David A, Wiggs Janey L, MacGregor Stuart, Craig Jamie E
Abstract excerpt
Open-angle glaucoma (OAG) is a major cause of blindness worldwide. To identify new risk loci for OAG, we performed a genome-wide association study in 3,071 OAG cases and 6,750 unscreened controls, and meta-analysed the results with GWAS data for intraocular pressure (IOP) and optic disc parameters (the overall meta-analysis sample size varying between 32,000 to 48,000 participants), which are glaucoma-related...
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