Article
Calcium channel blockers as drug repurposing candidates for gestational diabetes: Mining large scale genomic and electronic health records data to repurpose medications.
Pharmacological research - 1 Apr 2018
Goldstein Jeffery A, Bastarache Lisa A, Denny Joshua C, Roden Dan M, Pulley Jill M, Aronoff David M
Abstract excerpt
New therapeutic approaches are needed for gestational diabetes mellitus (GDM), but must show safety and efficacy in a historically understudied population. We studied associations between electronic medical record (EMR) phenotypes and genetic variants to uncover drugs currently considered safe in pregnancy that could treat or prevent GDM. We identified 129 systemically active drugs considered safe in pregnancy...
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