Article

Reassessing Metformin Safety in Pregnancy: Robust Disproportionality Mining of FAERS Uncovers De-novo Teratogenic Signals Across Multiple Fetal Organ Systems

2025-09-11

Abstract excerpt

<h4>Background: </h4> While metformin is increasingly prescribed for gestational diabetes mellitus (GDM) and polycystic ovary syndrome (PCOS) during pregnancy, its fetal safety profile remains incompletely characterized. This pharmacovigilance study systematically evaluates potential teratogenic risks and adverse perinatal outcomes associated with prenatal metformin exposure. <h4>Methods: </h4>: We conducted a di...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b8d86c1e-367e-5720-8059-e02347b16689
DOI: 10.22541/au.175756888.86320921/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Reassessing Metformin Safety in Pregnancy: Robust Disproportionality Mining of FAERS Uncovers De-novo Teratogenic Signals Across Multiple Fetal Organ SystemsDOI 10.22541/au.175756888.86320921/v1Read

Association between zidovudine and adverse pregnancy outcomes/congenital malformations: A pharmacovigilance study using FAERS dataSemantic proximity Read

Risk of Adverse Pregnancy Outcomes Associated with Sodium Valproate(VPA): A Disproportionality Analysis Using the FDA Adverse Event Reporting System (FAERS)Semantic proximity Read

Adverse Events During Pregnancy Associated with Third Generation Antiseizure Medications: A Real-World AnalysisSemantic proximity Read

Metformin exposure in first trimester of pregnancy and risk of all or specific congenital anomalies: exploratory case-control studySemantic proximity Read

Real world based on FAERS database:To explore the mining and analysis of adverse pregnancy events related to drug exposureSemantic proximity Read

Signal Mining and Analysis of Adverse Events in Children Using Growth Hormones: A Real-World Study Based on FAERSSemantic proximity Read

Comparing Existing Algorithms for Retrieving Pregnancy-related Adverse Event ReportsSemantic proximity Read

Signal Mining and Analysis of Adverse Events of Isotretinoin: 20-year real-world pharmacovigilance analysis based on the FAERS databaseSemantic proximity Read

Drug-induced glucose metabolism disorders: A disproportionality analysis based on the FAERS databaseSemantic proximity Read

Reported congenital malformations after exposure to non-tumour necrosis factor inhibitors: a retrospective comparative study in EudraVigilanceSemantic proximity Read

Comprehensive assessment of the associations between maternal diabetes and structural birth defects in offspring: a phenome-wide association study.Semantic proximity Read

Real-world pharmacovigilance study of voclosporin based on FAERS and VigiBaseSemantic proximity Read