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Epithelial–mesenchymal transition and plasticity in the developmental basis of cancer and fibrosis

15 Feb 2018

Abstract excerpt

Epithelial–mesenchymal transition (EMT) process epitomizes a change of cell phenotype that is typically reversible. Epithelial cells loosen cell–cell adhesion structures; including tight junctions, desmosomes, and adherens junctions, dismantle their polarity, and reorganize their cytoskeleton, switching from cytokeratins to vimentin intermediate filaments. Cells loosen connection to other cells and become...

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PMID: 29446197
DOI: 10.1002/dvdy.24620

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