Article
Colorectal Cancer-Associated Genes Are Associated with Tooth Agenesis and May Have a Role in Tooth Development.
Scientific reports - 14 Feb 2018
Williams Meredith A, Biguetti Claudia, Romero-Bustillos Miguel, Maheshwari Kanwal, Dinckan Nuriye, Cavalla Franco, Liu Xiaoming, Silva Renato, Akyalcin Sercan, Uyguner Z Oya, Vieira Alexandre R, Amendt Brad A, Fakhouri Walid D, Letra Ariadne
Abstract excerpt
Previously reported co-occurrence of colorectal cancer (CRC) and tooth agenesis (TA) and the overlap in disease-associated gene variants suggest involvement of similar molecular pathways. Here, we took an unbiased approach and tested genome-wide significant CRC-associated variants for association with isolated TA. Thirty single nucleotide variants (SNVs) in CRC-predisposing genes/loci were genotyped in a...
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