Article
Shwachman-Diamond Syndrome Protein SBDS Maintains Human Telomeres by Regulating Telomerase Recruitment.
Cell reports - 13 Feb 2018
Liu Yi, Liu Feng, Cao Yizhao, Xu Huimin, Wu Yangxiu, Wu Su, Liu Dan, Zhao Yong, Songyang Zhou, Ma Wenbin
Abstract excerpt
Shwachman-Diamond syndrome (SDS) is a rare pediatric disease characterized by various systemic disorders, including hematopoietic dysfunction. The mutation of Shwachman-Bodian-Diamond syndrome (SBDS) gene has been proposed to be a major causative reason for SDS. Although SBDS patients were reported to have shorter telomere length in granulocytes, the underlying mechanism is still unclear. Here we provide data to...
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