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SV40 intron, a potent strong intron element that effectively increases transgene expression in transfected Chinese hamster ovary cells

14 Feb 2018

Abstract excerpt

Chinese hamster ovary (CHO) cells have become the most widely utilized mammalian cell line for the production of recombinant proteins. However, the product yield and transgene instability need to be further increased and solved. In this study, we investigated the effect of five different introns on transgene expression in CHO cells. hCMV intron A, adenovirus tripartite leader sequence intron, SV40 intron, Chinese...

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PMID: 29441681
DOI: 10.1111/jcmm.13504

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