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Article

Epigenetic regulation of HIV-1 latency: focus on polycomb group (PcG) proteins

5 Feb 2018

Abstract excerpt

HIV-1 latency allows the virus to persist until reactivation, in a transcriptionally silent form in its cellular reservoirs despite the presence of effective cART. Such viral persistence represents a major barrier to HIV eradication since treatment interruption leads to rebound plasma viremia. Polycomb group (PcG) proteins have recently got a considerable attention in regulating HIV-1 post-integration latency as...

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PMID: 29441145
DOI: 10.1186/s13148-018-0441-z

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