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Article

Increased Activity of Cystathionine β-Lyase Suppresses 2-Aminoacrylate Stress in Salmonella enterica.

Journal of bacteriology - 1 May 2018

Ernst Dustin C, Christopherson Melissa R, Downs Diana M

Abstract excerpt

Reactive enamine stress caused by intracellular 2-aminoacrylate accumulation leads to pleiotropic growth defects in a variety of organisms. Members of the well-conserved RidA/YER057c/UK114 protein family prevent enamine stress by enhancing the breakdown of 2-aminoacrylate to pyruvate. In Salmonella enterica, disruption of RidA allows 2-aminoacrylate to accumulate and to inactivate a variety of pyridoxal...

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Identifiers

PMID: 29440255
DOI: 10.1128/JB.00040-18
PMCID: PMC5892115

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