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Article

Endogenous synthesis of 2-aminoacrylate contributes to cysteine sensitivity in Salmonella enterica.

Journal of bacteriology - 1 Sept 2014

Ernst Dustin C, Lambrecht Jennifer A, Schomer Rebecca A, Downs Diana M

Abstract excerpt

RidA, the archetype member of the widely conserved RidA/YER057c/UK114 family of proteins, prevents reactive enamine/imine intermediates from accumulating in Salmonella enterica by catalyzing their hydrolysis to stable keto acid products. In the absence of RidA, endogenous 2-aminoacrylate persists in the cellular environment long enough to damage a growing list of essential metabolic enzymes. Prior studies have...

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Identifiers

PMID: 25002544
DOI: 10.1128/JB.01960-14
PMCID: PMC4135687

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