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Two novel fish paralogs provide insights into the Rid family of imine deaminases active in pre-empting enamine/imine metabolic damage.

Scientific reports - 23 Jun 2020

Digiovanni Stefania, Visentin Cristina, Degani Genny, Barbiroli Alberto, Chiara Matteo, Regazzoni Luca, Di Pisa Flavio, Borchert Andrew J, Downs Diana M, Ricagno Stefano, Vanoni Maria Antonietta, Popolo Laura

Abstract excerpt

Reactive Intermediate Deaminase (Rid) protein superfamily includes eight families among which the RidA is conserved in all domains of life. RidA proteins accelerate the deamination of the reactive 2-aminoacrylate (2AA), an enamine produced by some pyridoxal phosphate (PLP)-dependent enzymes. 2AA accumulation inhibits target enzymes with a detrimental impact on fitness. As a consequence of whole genome...

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Identifiers

PMID: 32576850
DOI: 10.1038/s41598-020-66663-w
PMCID: PMC7311433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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