Article
Topoisomerase mutations associated with in vitro selection of resistance to moxifloxacin in Streptococcus pneumoniae.
Antimicrobial agents and chemotherapy - 1 Aug 2002
Houssaye Serge, Gutmann Laurent, Varon Emmanuelle
Abstract excerpt
We analyzed the frequencies of selection, the order of acquisition, and the mutations selected on moxifloxacin in two wild-type pneumococcal strains, R6 and 5714. The first selection step showed either a single GyrA mutation or no mutation in any of the quinolone resistance-determining regions. S...
Topics
- Amino Acid Substitution
- Anti-Infective Agents
- Aza Compounds
- DNA Gyrase
- DNA Topoisomerase IV
- DNA Topoisomerases, Type I
- Drug Resistance, Microbial
- Fluoroquinolones
- Microbial Sensitivity Tests
- Moxifloxacin
- Mutation
- Quinolines
- Streptococcus pneumoniae