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Article

Topoisomerase mutations associated with in vitro selection of resistance to moxifloxacin in Streptococcus pneumoniae.

Antimicrobial agents and chemotherapy - 1 Aug 2002

Houssaye Serge, Gutmann Laurent, Varon Emmanuelle

Abstract excerpt

We analyzed the frequencies of selection, the order of acquisition, and the mutations selected on moxifloxacin in two wild-type pneumococcal strains, R6 and 5714. The first selection step showed either a single GyrA mutation or no mutation in any of the quinolone resistance-determining regions. Second-step mutants selected had either a second mutation in ParC or in ParE. Moxifloxacin could belong to these...

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Identifiers

PMID: 12121964
DOI: 10.1128/AAC.46.8.2712-2715.2002
PMCID: PMC127326

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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