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Article

Polygenic Risk for Depression Increases Risk of Ischemic Stroke

8 Feb 2018

Abstract excerpt

BACKGROUND AND PURPOSE: Although depression is a risk factor for stroke in large prospective studies, it is unknown whether these conditions have a shared genetic basis. METHODS: We applied a polygenic risk score (PRS) for major depressive disorder derived from European ancestry analyses by the Psychiatric Genomics Consortium to a genome-wide association study of ischemic stroke in the Stroke Genetics Network of...

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PMID: 29438084
DOI: 10.1161/strokeaha.117.018857

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