Emphysema and extrapulmonary tissue loss in COPD: a multi-organ loss of tissue phenotype.

doi:10.1183/13993003.02146-2017

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Article

Emphysema and extrapulmonary tissue loss in COPD: a multi-organ loss of tissue phenotype.

The European respiratory journal - 1 Feb 2018

Celli Bartolome R, Locantore Nicholas, Tal-Singer Ruth, Riley John, Miller Bruce, Vestbo Jørgen, Yates Julie C, Silverman Edwin K, Owen Caroline A, Divo Miguel, Pinto-Plata Victor, Wouters Emiel F M, Faner Rosa, Agusti Alvar

Abstract excerpt

We tested whether emphysema progression accompanies enhanced tissue loss in other body compartments in 1817 patients from the ECLIPSE chronic obstructive pulmonary disease (COPD) cohort.Clinical and selected systemic biomarker measurements were compared in subjects grouped by quantitative tomography scan emphysema quartiles using the percentage of low attenuation area (LAA%). Lowest and highest quartile patients...

Topics

Adult
Aged
Biomarkers
Body Mass Index
Disease Progression
Female
Humans
Lung
Male
Middle Aged
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prospective Studies

Pulmonary Disease, Chronic Obstructive

Pulmonary Emphysema

Pulmonary Surfactant-Associated Protein D

Respiratory Function Tests

Severity of Illness Index

Smoking

Source

Open in PubMed

Identifiers

PMID: 29437944
DOI: 10.1183/13993003.02146-2017

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