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Article

Polymorphisms in P2X4R and CAMKK2 may affect TNFα production: Implications for a role in HIV-associated sensory neuropathy.

Human immunology - 1 Apr 2018

Gaff Jessica, Halstrom Samuel, Temple Suzanna E L, Baltic Svetlana, Kamerman Peter, Price Patricia

Abstract excerpt

Polymorphisms in P2X4R and CAMKK2 associate with susceptibility to HIV-associated sensory neuropathy (HIV-SN) - a condition likely mediated by TNFα. As single nucleotide polymorphisms (SNPs) and haplotypes of CAMKK2, and a neighbouring gene P2X4R, mark susceptibility to HIV-SN in South Africans living with HIV, we examined the relationship between P2X4R and CAMKK2 genotypes and TNFα production. Peripheral blood...

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Identifiers

PMID: 29428485
DOI: 10.1016/j.humimm.2018.02.002

Genes

CAMKK2

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