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Establishment of a mutation system in Tetrahymena outer arm dynein and P-loop functions of the alpha heavy chain (Dyh3p).

Biochemical and biophysical research communications - 29 Jan 2017

Edamatsu Masaki

Abstract excerpt

Axonemal dyneins are large AAA+ type motor proteins that exhibit unique motor properties during ciliary beating. This study established a mutation system for Tetrahymena outer arm dynein and characterized four nucleotide-binding loops (P-loops; P1-P4) in the alpha heavy chain (Dyh3p). Macronuclear transformation of the mutant DYH3 genes in DYH3-knockout (KO-DYH3) cells enabled P-loop mutations that abolish the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28069381
DOI: 10.1016/j.bbrc.2017.01.020

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