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Article

KRAS and 2 rare PI3KCA mutations coexisting in a metastatic colorectal cancer patient with aggressive and resistant disease.

Human pathology - 1 Apr 2018

Tessitore Alessandra, Bruera Gemma, Mastroiaco Valentina, Cannita Katia, Cortellini Alessio, Cocciolone Valentina, Dal Mas Antonella, Calvisi Giuseppe, Zazzeroni Francesca, Ficorella Corrado, Ricevuto Enrico, Alesse Edoardo

Abstract excerpt

We describe a metastatic colorectal cancer patient, treated with first-line 5-fluorouracil, irinotecan, bevacizumab, and oxaliplatin (FIr-BFOx) therapy, with aggressive and resistant disease. KRAS, NRAS, BRAF, and PI3KCA were analyzed in primary tumor and liver metastasis. KRAS c.34G>A mutation was detected in primary tumor and liver metastasis, which additionally revealed 2 rare PI3KCA mutations (c.1633G>C and...

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Identifiers

PMID: 29409955
DOI: 10.1016/j.humpath.2018.01.021

Genes

KRAS
BRAF
NRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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