Article
Mendelian randomisation study of the relationship between vitamin D and risk of glioma.
Scientific reports - 5 Feb 2018
Takahashi Hannah, Cornish Alex J, Sud Amit, Law Philip J, Kinnersley Ben, Ostrom Quinn T, Labreche Karim, Eckel-Passow Jeanette E, Armstrong Georgina N, Claus Elizabeth B, Il'yasova Dora, Schildkraut Joellen, Barnholtz-Sloan Jill S, Olson Sara H, Bernstein Jonine L, Lai Rose K, Schoemaker Minouk J, Simon Matthias, Hoffmann Per, Nöthen Markus M, Jöckel Karl-Heinz, Chanock Stephen, Rajaraman Preetha, Johansen Christoffer, Jenkins Robert B, Melin Beatrice S, Wrensch Margaret R, Sanson Marc, Bondy Melissa L, Turnbull Clare, Houlston Richard S
Abstract excerpt
To examine for a causal relationship between vitamin D and glioma risk we performed an analysis of genetic variants associated with serum 25-hydroxyvitamin D (25(OH)D) levels using Mendelian randomisation (MR), an approach unaffected by biases from confounding. Two-sample MR was undertaken using genome-wide association study data. Single nucleotide polymorphisms (SNPs) associated with 25(OH)D levels were used as...
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