Article
Impact of atopy on risk of glioma: a Mendelian randomisation study.
BMC medicine - 15 Mar 2018
Disney-Hogg Linden, Cornish Alex J, Sud Amit, Law Philip J, Kinnersley Ben, Jacobs Daniel I, Ostrom Quinn T, Labreche Karim, Eckel-Passow Jeanette E, Armstrong Georgina N, Claus Elizabeth B, Il'yasova Dora, Schildkraut Joellen, Barnholtz-Sloan Jill S, Olson Sara H, Bernstein Jonine L, Lai Rose K, Schoemaker Minouk J, Simon Matthias, Hoffmann Per, Nöthen Markus M, Jöckel Karl-Heinz, Chanock Stephen, Rajaraman Preetha, Johansen Christoffer, Jenkins Robert B, Melin Beatrice S, Wrensch Margaret R, Sanson Marc, Bondy Melissa L, Houlston Richard S
Abstract excerpt
BACKGROUND: An inverse relationship between allergies with glioma risk has been reported in several but not all epidemiological observational studies. We performed an analysis of genetic variants associated with atopy to assess the relationship with glioma risk using Mendelian randomisation (MR), an approach unaffected by biases from temporal variability and reverse causation that might have affected earlier...
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