Article
Optineurin mutations in patients with sporadic amyotrophic lateral sclerosis in China.
Amyotrophic lateral sclerosis & frontotemporal degeneration - 1 Jan 2015
Li Chengyu, Ji Ying, Tang Lu, Zhang Nan, He Ji, Ye Shan, Liu Xiaolu, Fan Dongsheng
Abstract excerpt
The purpose of this study was to assess the frequency of optineurin (OPTN) mutation in amyotrophic lateral sclerosis (ALS) patients from mainland China, as well as to characterize the relationship between OPTN mutation and clinical phenotypes. We examined the coding region of OPTN in 511 unrelated Chinese sporadic ALS (SALS) subjects and 204 healthy controls using a PCR direct sequencing strategy. Nine OPTN...
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