Article
Mutation spectrum of amyotrophic lateral sclerosis in Central South China.
Neurobiology of aging - 1 Nov 2021
Liu Zhen, Yuan Yanchun, Wang Mengli, Ni Jie, Li Wanzhen, Huang Ling, Hu Yiting, Liu Pan, Hou Xiaorong, Hou Xuan, Du Juan, Weng Ling, Zhang Ruxu, Niu Qi, Tang Jianguang, Jiang Hong, Shen Lu, Tang Beisha, Wang Junling
Abstract excerpt
To analyze the mutational spectrum of known ALS causative genes in China ALS patients. We comprehensively analyzed 51 ALS causative genes by combining different sequencing technologies in 753 unrelated ALS patients from Central South China. The mean age at onset (AAO) was 53.7±11.4 years. The AAO was earlier in the autosomal dominant (AD) ALS patients than in the sporadic ALS (sALS) patients. Bulbar onset was...
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