Donor PNPLA3 rs738409 genotype is a risk factor for graft steatosis. A post-transplant biopsy-based study.

doi:10.1016/j.dld.2017.12.030

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Article

Donor PNPLA3 rs738409 genotype is a risk factor for graft steatosis. A post-transplant biopsy-based study.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver - 1 May 2018

Trunečka Pavel, Míková Irena, Dlouhá Dana, Hubáček Jaroslav A, Honsová Eva, Kolesár Libor, Lánská Věra, Fraňková Soňa, Šperl Jan, Jirsa Milan, Poledne Rudolf

Abstract excerpt

BACKGROUND & AIMS: The rs738409 c.444C > G (p.I148M) polymorphism in PNPLA3 is a major factor predisposing to non-alcoholic fatty liver disease. The aim of the study was to clarify the impact of liver and extrahepatic expression of the PNPLA3 p.148M variant on liver graft steatosis after liver transplantation. METHODS: Fat content was assessed in liver biopsies from 176 transplant recipients. During a period of...

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PMID: 29396131
DOI: 10.1016/j.dld.2017.12.030

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PNPLA3

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