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Article

Disclosure of cardiac variants of uncertain significance results in an exome cohort.

Clinical genetics - 1 May 2018

Lawal T A, Lewis K L, Johnston J J, Heidlebaugh A R, Ng D, Gaston-Johansson F G, Klein W M P, Biesecker B B, Biesecker L G

Abstract excerpt

This study examined the impact of disclosing subclassifications of genetic variants of uncertain significance (VUS) on behavioral intentions. We studied return of VUS results to 79 individuals with a cardiomyopathy-associated VUS, subclassified into VUS-high or VUS-low. Primary outcomes were perceived risk (absolute and comparative), perceived severity, perceived value of information, self-efficacy, decision...

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Share to Cardiomyopathies
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

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Share to Sequence Analysis, DNA

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Source

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Identifiers

PMID: 29383714
DOI: 10.1111/cge.13220
PMCID: PMC5961741

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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