Article
Genetic polymorphisms of autophagy-related gene 5 (ATG5) rs473543 predict different disease-free survivals of triple-negative breast cancer patients receiving anthracycline- and/or taxane-based adjuvant chemotherapy.
Chinese journal of cancer - 31 Jan 2018
Li Meiying, Ma Fei, Wang Jiayu, Li Qing, Zhang Pin, Yuan Peng, Luo Yang, Cai Ruigang, Fan Ying, Chen Shanshan, Li Qiao, Xu Binghe
Abstract excerpt
BACKGROUND: Autophagy plays a crucial role in chemotherapy resistance of triple-negative breast cancer (TNBC). Hence, autophagy-related gene 5 (ATG5), an essential molecule involved in autophagy regulation, is presumably associated with recurrence of TNBC. This study was aimed to investigate the potential influence of single-nucleotide polymorphisms in ATG5 on the disease-free survival (DFS) of early-stage TNBC...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.